Phenotypic assays for analysis of pluripotent stem cell derived cardiomyocytes

Result type
journal article in Web of Science database
Description

A novel approach combining atomic force microscopy, fluorescent microscopy, and external electrophysiology through microelectrode arrays is introduced. The paper demonstrates that this novel method can be used to gain unique information on the complex excitation-contraction coupling dynamics of the hPSC-derived CMs.

Keywords
atomic force microscopy
cardiomyocytes
differentiation
drug screening
drug toxicity
hESC
hiPSC
high-throughput screening